BioISI Researcher Ana Margarida Fortes on the team of vWISE, an European Project
BioISI researcher Ana Margarida Fortes is part of the team of the recently funded European project "Vine and Wine Innovation through Scientific Exchange (vWISE)", coordinated by the University of Bordeaux. The vWISE project focuses on addressing the impact of climate change on vineyards, grapes and wines, which poses a considerable threat [...]
BioISI Researchers published two papers in two prestigious international journals
Researchers from BioISI's Chemistry for Biological Systems Group (Computational Chemistry Lab led by Paulo J. Costa ) published two papers in two prestigious international journals, one in Expert Opinion on Drug Discovery, the other in the Journal of Chemical Theory and Computation In these, Paulo J. Costa, Diogo Vila Viçosa e Rafael Nunes discuss and [...]
1st BioISI PhD Symposium
Lisboa (Portugal) 28 June 2019 We are planning a special day to gather and share some science. We will catch up on our latest results and have some time to celebrate. We want to invite all the community to join us and so have a fruitful discussion. It will take place on Auditório do Caleidoscópio, [...]
Tyrosine phosphorylation modulates cell surface expression of chloride cotransporters NKCC2 and KCC3
Cláudia AlmeidaLoureiro, PatríciaBarros, PauloMatos, PeterJordan Cellular chloride transport has a fundamental role in cell volume regulation and renal salt handling. Cellular chloride entry or exit are mediated at the plasma membrane by cotransporter proteins of the solute carrier 12 family. For example, NKCC2 resorbs chloride with sodium and potassium ions at the apical membrane [...]
Halogen bonding in halocarbon-protein complexes and computational tools for rational drug design
Paulo J. Costa, Rafael Nunes & Diogo Vila-Viçosa (2019) Halogen bonding in halocarbon-protein complexes and computational tools for rational drug design,Expert Opinion on Drug Discovery Introduction: Halogens have a prominent role in drug design. Often used as a mean to improve ADME properties, they are also becoming a tool in protein–ligand recognition given their [...]
BioISI Post Graduate Seminars, May 21, FCUL
Room 1.3.33 A- May 21, 17h Miguel Vitorino DAEPHYS PhD student, Bio-PhysNano Going nano: exploring biological physics through atomic force microscopy Atomic force microscopes (AFMs) had a critical role in the exploration of the nanoscale over the last decades. In particular, they are fundamental to the latest interdisciplinary effort [...]
BioISI Research Seminar, May 2 – Paulo Costa, 11h30, FCiências.ID Auditorium
FCiências.ID Auditorium- May 2 , 11h30 Paulo J Costa CQB | BioISI | FCUL Halogen bonds: how do we model them? Halogenated compounds have a prominent role in drug discovery, often aiming at improving drug-like properties such as membrane permeability or pharmacokinetic stability. Additionally, they often bind to their [...]
2019 Summer School on Epithelial Systems: Physiology and Pathophysiology
Lisboa (Portugal) 22 – 26 July 2019 FREE REGISTRATION! DEADLINE FOR REGISTRATION EXTENDED: JUNE 12 Limited registrations: 20 participants Learn about the latest developments on Epithelial Systems: Physiology and Pathophysiology and discuss your project with the experts Workshop Overview Participants will learn about the latest developments in Epithelial Systems: Physiology and Pathophysiology. Besides the opportunity to discuss [...]
BioISI Post Graduate Seminars, April 16 – Tomás Silva and Márcia Faria
FCiências.ID Amphitheatre - April 16, 17h Tomás Silva PhD Student - CBS Computational study of pH-dependent membrane insertion of pHLIP peptides The pH (low) insertion peptide (pHLIP) belongs to a family of transmembrane peptides, with the ability to insert in membrane cells dependent on how acidic is their vicinity, [...]