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MSc/PhD programmes – ITQB-NOVA

2017-11-23T15:47:58+00:00 November 23rd, 2017|

Drs. Federico Herrera and Manuel Melo are looking for promising candidates to carry out a multidisciplinary MSc or PhD in the frontier between of computational biology, mathematics and protein structure in an exciting research environment. Subject: Development of new mathematical and computational tools to predict protein complementation Scientific background: Some proteins can be divided in non-functional fragments [...]

High-Throughput Microscopy Workshop 2017

2018-01-16T11:59:32+00:00 November 23rd, 2017|

The workshop is directed for PhD Students, Post-Docs, Microscopy Technicians and Independent Researchers. Participants are expected to be acquainted with the basics of Widefield Fluorescence Microscopy. No prior experience with High-Throughput techniques is required. This workshop is having place on 17 – 21 July 2017, Lisbon (Portugal). Fee for external students: 100 euros. For more information [...]

Hands-on Workshop Epithelial Systems

2018-01-16T13:38:36+00:00 November 23rd, 2017|

Hands-on Workshop Epithelial Systems: physiology and pathophysiology 24-28 July 2017 The workshop includes lectures, tutorials and hand-on practicals. There is no fee (Supported by ECFS). And travel grants may be awarded to students from The Netherlands, France and Germany, by their CF patients organizations. Limited to 16 participants only, so hurry up with the application. Applications [...]

Master and PhD positions abroad

2018-01-16T13:40:13+00:00 November 23rd, 2017|

Master and PhD positions abroad - Univ. Regensburg The team of Prof. Karl Kunzelmann and that of Prof. Margarida Amaral at the Faculty of Sciences / University of Lisbon collaborate closely  a productive lab with an international team. Join them! Topic - CFTR and anoctamins in cystic fibrosis Lung disease are very common and often [...]

An attractive possibility to treat Cystic Fibrosis

2018-02-21T17:17:42+00:00 November 23rd, 2017|

A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic An attractive possibility to treat Cystic Fibrosis (CF), a severe condition caused by dysfunctional CFTR, an epithelial anion channel, is through the activation of alternative (non-CFTR) anion channels. Anoctamin 1 (ANO1) was demonstrated to be a Ca(2+)-activated chloride channel [...]

Wine With Science Hangout

2018-03-20T18:12:57+00:00 July 31st, 2012|

Inserted in the Science and Technology week, from 23rd to 29th November. There is going to be a social gathering to talk about science while tasting wine on the 24th of November in the bar of Faculdade de Ciências da Universidade de Lisboa. You can also attend the public Workshops: ‘The genome just one click away’ and ‘From [...]

Science & Technology Week 2017

2018-03-20T18:10:18+00:00 July 31st, 2012|

From 23rd to 29th November we are celebrating the Science and Technology week. Come join us for various activities like, from talks to workshops and social gatherings. Workshops for general public: ‘The genome just one click away’ and ‘From a magnifying glass to atomic force microscopy – searching for the minions’. Hangout Session to talk about Science and [...]

CFTR folding and trafficking

2018-01-16T11:36:33+00:00 July 31st, 2012|

From the endoplasmic reticulum to the plasma membrane: mechanisms of CFTR folding and trafficking CFTR biogenesis starts with its co-translational insertion into the membrane of endoplasmic reticulum and folding of the cytosolic domains, towards the acquisition of a fully folded compact native structure. Efficiency of this process is assessed by the ER quality control system [...]

Current status of the field of knotted proteins

2012-07-31T17:23:05+00:00 July 31st, 2012|

Knotted proteins: A tangled tale of Structural Biology Abstract Knotted proteins have their native structures arranged in the form of an open knot. In the last ten years researchers have been making significant efforts to reveal their folding mechanism and understand which functional advantage(s) knots convey to their carriers. Molecular simulations have been playing a [...]

CF and Antisense Oligonucleotides

2012-07-31T17:22:22+00:00 July 31st, 2012|

Correction of a Cystic Fibrosis Splicing Mutation by Antisense Oligonucleotides Cystic fibrosis (CF), the most common life-threatening genetic disease in Caucasians, is caused by ∼2000 different mutations in the CF transmembrane conductance regulator (CFTR) gene. A significant fraction of these (∼13%) affect pre-mRNA splicing and for which novel therapies have been somewhat neglected. We have [...]