New PhD Fellowship @ grant- Personalised Therapies for all: Restoring airway function in CF using Alternative Chloride Channels (ACCs)
This fully-funded 3.5 year PhD is part of a Strategic Research Centre (SRC) grant – Personalised Therapies for all: Restoring airway function in CF using Alternative Chloride Channels (ACCs), that aims to develop new therapeutic strategies to restore airway function in all people with CF using a personalised therapeutic approach. The SRC is a multi-national project involving groups in the UK, Holland, Portugal and Germany. The aim of this PhD is to determine individual donor responses to ACC modulators alone,or in combination with CFTR modulators,on ASL pH, trans epithelialion,fluid,and mucus transport in fully differentiated 2D and 3D adult and paediatric CF airway cultures in vitro. During the first year the student will spend 1 month in the lab of Dr. Jeff Beekman (Utrecht University),to gain experience in the differentiated procedure to produce 3D airway organoids, as well as organoid functional assays (e.g. fluid secretion assay). All SRC members will meet annually at the CF Basic Science conference (https://www.ecfs.eu/conferences) to discuss progress and future directions.
Deadline for applications: 18 July 2018
Award and Eligibility
The award provides an annual tax-free stipend in line with the Cystic Fibrosis Trust rate (currently £19,919; with annual increment). UK/EU and International applicants that have, or expect to achieve, a first-class or upper-second-class Honours degree (or equivalent)in a relevant Biomedical science subject are eligible to apply; however,the award only covers tuition fees at the UK/EU rate.