PBS – Physics of Biological Systems Lino Almeida
PBS – Physics of Biological Systems
Physics of Biological Systems Group
main aim is to apply quantitative methods for biologically motivated problems, developing modeling approaches with a focus on the study of proteins with medical interest and of infectious diseases.
The group is currently located at the Instituto para a Investigação Interdisciplinar (III-UL) in the University of Lisbon campus, within walking distance from FCUL, with excellent infrastructures to store the groups computer facilities (currently composed of 12 workstations and three computer clusters). The PBS group is composed of two research teams focusing on population dynamics and protein physics. A number of methodologies based on statistical and computational physics are used across both research lines prompting cross-collaborations between the teams, as shown by several co-authored papers.
Key areas of research of the PBS group include: 1) Contact networks, epidemic spread and viral evolution; 2) Protein aggregation in amyloidosis; 3) Physical basis of prionogenesis; 4) Misfolding and gating of CFTR; 5) Folding under confinement.
Specific interdisciplinary research aims in collaboration with other BioISI groups are a comprehensive study of the aggregation mechanism of b2m that will combine simulation predictions (for the structure and stability of dimers and higher order aggregates) with experimental measurements based on force-feed-back microscopy (within the goals of the Condensed Matter and Biological Physics thematic line), a large-scale agent based model simulations of epidemic spread incorporating a statistical description of human mobility and the physical modelling of CFTR with potential applications to rational drug design framed on small chemical chaperones (both within the Bioinformatics and Modelling thematic line goals).
PIs: Patrícia Faísca | Ana Maria Nunes
Post Doc: Sílvia Estácio (left June 2015)
PhD Students: Rui J Loureiro (BioSYS)
Stefan Wieland and Ana Nunes (2015) Analytic description of adaptive network topologies in a steady state, Phys. Rev. E, 91, 060801(R) (Rapid Communication). PMID
Ramona Marguta and Andrea Parisi (2015) Impact of human mobility on the periodicities and mechanisms underlying measles dynamics, J. R. Soc. Interface, 12, 20141317. PMID
Heinrich Krobath, Antonio Rey, Patrícia F.N. Faísca (2015) How determinant is N-terminal to C-terminal coupling for protein folding? Phys. Chem. Chem. Phys. 17, 3512-3524. PMID