The main focus of BioISI research in the Biomedicine thematic line (BioMed-TL) is to gain a better mechanistic understanding of diseases, with an emphasis on those with a genetic basis. To this end BioISI researchers will use the advances resulting from the knowledge of the human genome by analysing how each individual gene contributes to processes associated with diseased states.
BioMed-TL research will thus range from basic biomedical research in genetics and genomics, molecular & cell biology and Omics to more translational areas such as addressing fundamental challenges in personalized medicine for better diagnosis, prognosis and therapies. The latter coincides with the health streamline priority of H2020 of personalising health and care.
Research Groups mainly involved in the BioMed – TL
FunGP | GER | BTR
1. Translating genes and genomics into personalized and systems medicine
2. Elucidating mechanisms of disease
3. Development of innovative therapeutic strategies and drug discovery
4. Pharmaco-genetics and pharmaco-resistance tests
BioTech - Biotechnology
The research to be performed in the Biotechnology thematic line (BioTech-TL) is framed by the H2020 societal challenges: Health and Wellbeing [Functional foods for disease prevention, environmental rehabilitation, new drugs from marine organisms], food security and sustainable agriculture; and by the H2020 key enabling technologies: Advanced materials [nutraceuticals], Biotechnology.
Research will be conducted to acquire knowledge and develop modular tool kits that will enable rapid responses to unforeseen challenges, such as the emergence of new plant or diet-related diseases, changes in the distributions of plant pathogens and vectors, the emergence of new environmental conditions or the impact assessment of new bio-based products.
Research Groups mainly involved in the BioTech – TL
PFG | M&B | CBS
1. Plant health and crop improvement
2. Plants as Biofactories
4. Microbial pharmacogenomics
5. Marine microbial biotechnology
6. Wine microbial biotechnology
BioPhys - Biophysics
The thematic line BioPhysics (BioPhys-TL) merges together the expertise of experimental condensed matter physicists and theoretical biological physicists and takes advantage of the unique research opportunities offered by the multidisciplinary environment of BioISI to foster interdisciplinary work through tailored interactions among members of these two Physics groups and members of all Biology groups. The research program of BioPhys-TL develops around three Key Actions (KA) as flagship projects as described below.
Research Groups mainly involved in the BioPhys– TL
CBS | BioPhysNano
1. Development and/or refinement of Atomic Force Microscopy (AFM)/Force Feedback Microscopy (FFM)
2. Development of novel simulation approaches to study protein (mis)folding
3. Optimization of nanostructured magnetic systems for application to biosensors/biodevices
BioInf - Bioinformatics
The main scientific goal of Bioinformatics thematic line (BioInf-TL) is twofold: to research fundamental properties of bio inspired models and to gather BioISI research around the common goal of cell system modelling.
BioInf-TL aggregates research of BioISI concerning computational models and tools for molecular, biological, biomedical and social systems. The scope of modelling in BioISI is vertical in terms of systems, from physical basis of biological systems to social organisation of such systems. Agent based modelling and simulation are basic techniques widely used in the BioInf-TL.
Seven research groups of BioISI (indicated in each key action) have activities that converge into BioInf-TL. In common all work with numerical and algorithmic models of living systems for which computational implementations are fundamental. In particular, we can identify computer processing activities typical of BioInf–TL.
Research Groups mainly involved in the BioInf – TL
GER | MAS
1. Pre-processing pipelines for data analysis
2. Data mining tools and data analysers
3. Development of new computational tools to manage, integrate and interpret the data
BChem – Biological Chemistry
The thematic line Biological Chemistry (BChem) aims at using chemical knowledge at the molecular level to design better drugs, understand structural changes triggered by the environment (such as pH or binding of a substrate), or determine mechanisms involved in enzyme functionality and bioenergetics. These integrating (bio)chemical approaches converge in many projects related with understanding and solving health problems and environmental safety.
The BChem line contributes to i) the development of new bioactive molecules, by organic or inorganic synthesis or by extraction from natural sources (mainly marine organisms and plants); ii) the computational (quantum-chemical and molecular modeling methods) and experimental study of systems ranging from the (in)organic to biochemical and cellular levels.