Lopes JML, Campos VR, Reis AC, Matos EM, Azevedo ALS, Machado AM, Grazul RM, Viccini LF.

Aneuploidy is associated with add or lack of individual chromosomes. The knowledge regarding aneuploidy is still rare in wild and tropical populations. Lippia alba is a tropical polyploid complex naturally formed, with 2x, 3x, 4x, 6x, and aneuploid individuals. The species presents pharmacological and medicinal importance, due to its essential oil compounds, which are related to the ploidal level. Considering the singularity of aneuploids emergence and stability, we proposed to investigate putative cytotypes involved in the aneuploids formation.

Molecular, cytogenetic, reproductive, and chemical approaches were adopted. The results showed that the aneuploids possibly have independent origin considering the genetic, chemical and karyotypical profiles. The chemical composition of aneuploids is related to genetic similarity. The aneuploid origin may involve 2x and 3x cytotypes being possible to rise four scenarios of crosses to explain that.

The results, in general, contribute to the comprehension of the origin of aneuploids and highlight the genetic profile of these accessions as a key element on the understanding of the chemical profile of L. alba accessions.

Doi: 10.1007/s11033-022-07599-4

Lopes JML, Campos VR, Reis AC, Matos EM, Azevedo ALS, Machado AM, Grazul RM, Viccini LF (2022) Molecular mechanisms of Cystic Fibrosis – how mutations lead to misfunction and guide therapy complex: genetic aspects and origin. Molecular Biology Reports, , . doi: 10.1007/s11033-022-07599-4