FunGP – Functional Genomics and Proteostasis

Margarida Amaral

Recent Publications
Identification of novel F508del-CFTR traffic correctors among triazole derivatives
Bacalhau M, Ferreira FC, Kmit A, Souza FR, da Silva VD, Pimentel AS, Amaral MD, Buarque CD, Lopes-Pacheco M. (2022) Identification of novel F508del-CFTR traffic correctors among triazole derivatives. European Journal of Pharmacology, , . doi: 10.1016/j.ejphar.2022.175396
Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids
Rodenburg LW, Delpiano L, Railean V, Centeio R, Pinto MC, Smits SMA, van der Windt IS, van Hugten CFJ, van Beuningen SFB, Rodenburg RNP, van der Ent CK, Amaral MD, Kunzelmann K, Gray MA, Beekman JM, Amatngalim GD (2022) Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(20), 12657. doi: 10.3390/ijms232012657
A Drug Screening Reveals Minocycline Hydrochloride as a Therapeutic Option to Prevent Breast Cancer Cells Extravasation across the Blood–Brain Barrier
Godinho-Pereira J, Lopes MD, Garcia AR, Botelho HM, Malhó R, Figueira I, Brito MA (2022) A Drug Screening Reveals Minocycline Hydrochloride as a Therapeutic Option to Prevent Breast Cancer Cells Extravasation across the Blood–Brain Barrier. Biomedicines, 10(8), 1988. doi: 10.3390/biomedicines10081988
Tetramerization of the S100B chaperone spawns a Ca2+ independent regulatory surface that enhances anti-aggregation activity and client specificity
Figueira AJ, Moreira GG, Saavedra J, Cardoso I, Gomes CM (2022) Tetramerization of the S100B chaperone spawns a Ca2+ independent regulatory surface that enhances anti-aggregation activity and client specificity. JOURNAL OF MOLECULAR BIOLOGY, , 167791. doi: 10.1016/j.jmb.2022.167791
Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus
Fernandes C, Palma E, Silva F, Belchior A, Pinto CIG, Guerreiro JF, Botelho HM, Mendes F, Raposinho P, Paulo A (2022) Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23, 7238. doi: 10.3390/ijms23137238
Severity of the S1251N allele in cystic fibrosis is affected by the presence of the F508C variant in cis
Cuyx S, Ramalho SS, Callebaut I, Cuppens H, Kmit A, Arnauts K, Ferrante M, Verfaillie C, Ensinck M, Carlon MS, Boon M, Proesmans M, Dupont L, De Boeck K, Farinha CM, Vermeulen F, Ramalho AS (2022) Severity of the S1251N allele in cystic fibrosis is affected by the presence of the F508C variant in cis. JOURNAL OF CYSTIC FIBROSIS, , . doi: 10.1016/j.jcf.2022.05.013