FunGP – Functional Genomics and Proteostasis

Margarida Amaral

The main goal of the Functional Genomics and Proteostasis Group is to understand human diseases and achieve drug discovery using functional genomics and systems approaches along with molecular and cell biology approaches.

FunGP is organized into five research labs, each headed by a PI. Each team explores independent scientific aims but with common interests and contributing to 3 out of the 4 major thematic lines of BioISI. Three of the groups have an international reputation in the frontline research of the competitive field of the monogenic disease Cystic Fibrosis, while the remaining two are leaders in signal transduction in cancer and pharmaco-resistance in malaria. The group also includes two Visiting Professors with double-affiliation to non-Portuguese institutions.

The major research topics of the FunGP group are focused on molecular and systems biology of Cystic Fibrosis (CF), cancer and malaria; studies of membrane proteins associated with human diseases; pharmacogenomics and drug development; biomarker identification; biodevices for point-of care medicine, diagnosis and prognosis.

Specific lines of interest include: 1) novel cellular epithelial models for CF studies; 2) molecular and cellular mechanisms of quality control of the endoplasmic reticulum and secretory traffic of the CFTR protein; 3) characterization of signal transduction pathways influencing oncogenic reprogramming of epithelial cells; 4) influence of host-pathogen genomes on the efficacy of drugs with a strong interest in drug transporter proteins; 5) identification of drug targets and drug screens target screens in cancer and chronic diseases

FunGP members are mainly associated with BioISI’s thematic line of Biomedicine but cooperative projects are being developed for integrative research within the thematic lines of Biophysics (for biodevice development) and Bioinformatics.

Team

Group Leader: Margarida Amaral msamaral@fc.ul.pt

PI’s:  Carlos Farinha | Paulo Matos | Cláudio Gomes | Luka Clarke | José Pedro Gil

Post Docs: Bárbara Henriques | Catarina Baptista | Hugo Botelho| Ines Pankonien | Iris Silva | Javier Fernández | Miquéias Lopes-Pacheco | Patrícia Barros |  Susana Igreja |

PhD Students:  Ana Matos (BioSys) | André Lamúrias (BioSys) | Catarina Pereira (BioSys) | Daniel Cruz (BioSys) | Filipa Simões (BioSys) | Joana Cristovão | Joana Lérias (BioSys)| João Santos (BioSys) | Lúcia Santos (BioSys) | Luís Sousa (BioSys) | Madalena Pinto (BioSys)| Márcia Faria (BioSys) | Margarida Quaresma (BioSys) | Mariana Romão (BioSys) | Sara Canato (BioSys)| Tânia Lucas | Verónica Felício

Technicians: Sofia Correia | Luís Marques

Recent Publications

Hafnium(IV) Chemistry with Imide−Dioxime and Catecholate−Oxime Ligands: Unique {Hf5} and Metalloaromatic {Hf6}−Oxo Clusters Exhibiting Fluorescence

Passadis SS, Hadjithoma S, Fairbairn NJ, Hedley GJ, Bandeira NAG, Tsipis AC, Miras AN, Keramidas AD, Kabanos TA (2022) Hafnium(IV) Chemistry with Imide−Dioxime and Catecholate−Oxime Ligands: Unique {Hf5} and Metalloaromatic {Hf6}−Oxo Clusters Exhibiting Fluorescence. Inorganic Chemistry, , . doi: 10.1021/acs.inorgchem.2c01768

Untargeted Metabolomics Reveals Antidepressant Effects in a Marine Photosynthetic Organism: The Diatom Phaeodactylum tricornutum as a Case Study

Duarte B, Feijão E, Cruz de Carvalho R, Duarte I, Marques AP, Maia M, Hertzog J, Matos AR, Cabrita MT, Caçador I, Figueiredo A, Silva MS, Cordeiro C, Fonseca VF (2022) Untargeted Metabolomics Reveals Antidepressant Effects in a Marine Photosynthetic Organism: The Diatom Phaeodactylumtricornutum as a Case Study. Biology, 11(12), 1770. doi: 10.3390/biology11121770