fmalberto@fc.ul.pt

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So far fmalberto@fc.ul.pt has created 12 blog entries.

Current status of the field of knotted proteins

2012-07-31T17:23:05+00:00 July 31st, 2012|

Knotted proteins: A tangled tale of Structural Biology Abstract Knotted proteins have their native structures arranged in the form of an open knot. In the last ten years researchers have been making significant efforts to reveal their folding mechanism and understand which functional advantage(s) knots convey to their carriers. Molecular simulations have been playing a [...]

CF and Antisense Oligonucleotides

2012-07-31T17:22:22+00:00 July 31st, 2012|

Correction of a Cystic Fibrosis Splicing Mutation by Antisense Oligonucleotides Cystic fibrosis (CF), the most common life-threatening genetic disease in Caucasians, is caused by ∼2000 different mutations in the CF transmembrane conductance regulator (CFTR) gene. A significant fraction of these (∼13%) affect pre-mRNA splicing and for which novel therapies have been somewhat neglected. We have [...]