The Chemistry for Biological Systems (CBS) Group opens one position to be filled by a MSc Student or a candidate enrolled in an academic or non-academic course of study. The selected candidate will work in a research group based at the Faculty of Sciences of the University of Lisbon.
Admission requirements: • Students enrolled in a Masters or with a Degree and/or with a Masters enrolled in an academic or non-academic course of study; • Experience in Computational Chemistry – quantum methods, molecular mechanics, or molecular simulation; • Scientific peer-reviewed publication(s) in the field.
Workplan:Study of the mechanism of breaking the phosphoester bond in models such as ATP, p-nitrophenylphosphate, bis-4-nitrophenylphosphate and 2-hydroxypropyl-4-nitrophenylphosphate, using polyoxometalates of the type [Mo7O26]6- and Na4[Mo8O26(proO)2]. The objectives of this work are to determine the relevant intermediates and, when possible, the transition states and the spectroscopic characterization of the species involved, as well as the energetics of the process.
Application: e-mail email@example.com and firstname.lastname@example.org with your CV, Qualifications Certificate, Proof of enrollment in an academic or non-academic course of study, and motivation letter.
A MSc Research fellowship is available at FunGP Lab, Functional Genomics and Proteostasis Lab, BioISI, Faculty of Sciences, University of Lisbon. The position is starting October 1, 2019 and the focus of the work is on performing high-throughput screening and validation assays to identify novel drugs that correct the processing and trafficking of CFTR mutants. This is a fellowship under the project Gilead School Award – “Identification of novel CFTR traffic correctors among FDA-approved drugs”, co-financed by the Gilead Sciences, Inc.
The Gene Expression and Regulation Group opens one position to be filled at doctoral level. The selected candidate will work in a research group based at Departamento de Genética Humana, Instituto Nacional de Saúde Doutor Ricardo Jorge, and will be invited to apply to a FCT PhD Research Scholarship.
Admission requirements: • MSc degree in Molecular/Cell Biology, Biochemistry, Pharmacy, Chemistry or related disciplines; • Highly motivated student with excellent academic performance; • Previous research experience demonstrated by a scientific peer-reviewed publication(s); • Availability for short lab-training abroad.
Workplan: Control of protein synthesis and its function in colorectal cancer (CRC); identification of proteins synthesized by non-canonical mechanisms of translation initiation important for metastization, and better understanding of the processes in which they are involved in CRC progression, with the final aim to design new CRC therapies. Methodological approaches will include molecular biology and biochemical techniques for quantification and characterization of mRNAs and interacting proteins, including RT-qPCR, Western blots, immunoprecipitations, dual luciferase assays, proteomics, and transcriptomics in cultured cells.
Application: e-mail email@example.com with your CV, publication list, motivation letter, and two recommendation letters, indicating availability for a personal/telephone interview.
Deadline: March 8th.
Fellowship for a Post-doctoral researcher
This is a call within the scope of the project DysMut2 – Characterization of Dysfunctional Mechanisms in Class II Mutation
Doctoral degreein Biochemistry, Biology, or akin areas, obtained less than 3 years ago, not done at BioISI;
Familiarity with Biochemistry and Molecular Biology techniques;
Relevant experience in molecular cloning techniques, protein biochemistry and mammalian cell culture.
Workplan: Production and analysis of bronchial cell lines with stable expression of variants of the CFTR protein.
This internship call targets undergraduate and MSc students and gives the successful candidate the opportunity to experience the world of very cutting edge genomics research.
We are currently seeking two highly motivated candidates to participate in the development of novel cutting-edge analytical procedures on a new international state-of-the-art core facility.
Admission requirements: – BSc in Biology, Biochemistry or similar; – Currently enrolled in a MSc degree in Biology, Biochemistry, Microbiology, Bioengineering or similar; – Experience in Molecular Biology.
Applicants will take part in two stage selection process including interview. The final decision will be communicated to the selected candidates as soon as both positions are filled. The decision is final and no further correspondence will take place with the applicants.
For more information, contact firstname.lastname@example.org or go here.
PhD Fellowship @ University of Regensburg (Germany)
Enrol at Uni-Regensburg (Germany) and receive a proper fellowship, in a well-funded productive laboratory with an international team, working on cutting edge scientific questions using modern techniques.
There is an open call for a PhD Fellowship, at the Dpt of Physiology – for a project in which BioISI Group FunGP participates.
This project consists of the identification of small molecules for a novel treatment of cystic fibrosis/asthma/polycystic kidney disease/cancer and understanding their molecular action.
The methods used are:
patch clamping and other electrophysiological techniques;
standard protein biochemistry and immunocytochemistry;
low throughput screening.
For more information, contact Prof. Dr. Karl Kunzelmann, at email@example.com (Group Leader) or Prof. Dr. M. Amaral (Colaborator from Faculty of Sciences/University of Lisboa), at firstname.lastname@example.org.