GER – Gene Expression and Regulation Lino Almeida
GER – Gene Expression and Regulation
The main goal of the
Gene Expression and Regulation Group
is to explore the regulation of eukaryotic gene expression programs at the transcriptional and post-transcriptional levels and their connection to signaling pathways, using a combination of cell and molecular biology studies with transcriptomics and bioinformatic approaches.
The group aims to tackle scientific problems that are relevant for human health and disease therapy and to explore applications to the development of targeted therapeutic strategies bridging Gene Expression Mechanisms to Systems Function and Therapy Development. The group is composed of four research teams located at the academic campus of FCUL (RNA Biology and Bioinformatics lab, lead by the group coordinator), the INSA campus (‘Signaling pathways in gene expression lab’ and the ‘mRNA Metabolism lab’), and at the University of Trás-os-Montes (‘Genome organization lab’). Each team explores independent but interconnected scientific aims within the overall objectives, contributing towards the development of a coherent research program in the area of eukaryotic control of gene expression.
A significant part of the group’s research involves the application and development of bioinformatic tools for RNA-seq data analysis, supported by a server infrastructure with capacity for analysis of eukaryotic transcriptomes.
Specific research interests include: 1) basic mechanism of gene expression and RNA-based therapy developments; 2) characterization of gene expression pathways underlying rare genetic disorders; 3) role of RNA pathways in neuronal function and neurodegeneration; 4) signaling pathways in cell function and cancer and their connection to splicing; 5) translational control and mRNA surveillance in cell function and cancer; 6) role of repetitive DNA sequences in genome organization and function.
Due to the focus on fundamental pathways for cell function and regulation and the extended use of transcriptomics and bioinformatic approaches, the GE&R group is in a pivotal position within BioISI contributing towards all thematic strands (TS) and being particularly involved in the Biomedicine and Bioinformatics and Modeling TS.
PI’s: Margarida Gama-Carvalho | Peter Jordan | Luísa Romão | Raquel Chaves
Post-Docs: Andreia Amaral | Christian Ramos | Juliane Menezes | Maria Filomena Adega | Vânia Gonçalves
PhD Students: Andreia Henriques (BioSys)| Hugo Santos (BioSys)| Paulo Costa (BioSys)| Daniel Olivença (BioSys)| Cláudia Loureiro (BioSys)| Nuno Domingues (BioSys)| Joana Silva (BioSys)| Daniela Ferreira | Ana Cristina Mendes da Silva | Ana Cláudia Escudeiro | Joana Pereira | Rafaela Santos
Other researchers: Gerson Amaral | João Paulo Silva | Marina Garcia-Vaquero | Nuno Costa | Cláudia Estima | André Gabriel | Cláudia Onofre | Susana Meles | Ana Luísa Borges |Ana Maria Vieira da Silva
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Pereira FJC et al. (2015). The extension of the AUG-proximity effect for nonsense-mediated decay inhibition is determined by the mRNA secondary structure. Nucleic Acids Research, 43: 6528-6544. PMID
Ferreira DP, et al (2015). Satellite Non-Coding RNAs: the emerging players in Cells, Cellular Pathways and Cancer. Chromosome Research 23(3):479-493. PMID